Thermoplastic polyurethane (TPU) is a versatile polymer widely used in implantable medical devices due to its excellent mechanical properties and biocompatibility also shows good resistance to wear, chemicals, and body fluids, It is suitable for devices that stay in the body for years. Solvent casting is commonly used because it is simple, cost-effective, and suitable for producing thin polymer films. This study compares two fabrication methods for TPU sheets (1) the traditional solvent casting technique and (2) solvent casting using a film applicator (doctor-blade method). This article provides a comprehensive overview of solvent casting in biomedical applications and describes the materials and procedures for each method. Process parameters including processing steps, drying time, dry film thickness uniformity, mechanical strength, and surface morphology are evaluated. The film applicator method is found to produce more uniform thickness films with improved consistency in mechanical performance and surface smoothness compared to traditional casting, which is simpler but can yield non-uniform thickness and rough surfaces. The advantages and limitations are explained for each. The framework allows incorporation of user-provided experimental data for direct comparison of film properties. This approach can support the development of more reliable and high-performance implantable medical devices. These insights guide the selection of an appropriate casting technique for high-quality TPU implantable sheet.