Background: Cardiopulmonary Resuscitation (CPR) is a lifesaving skill essential for nurses who often encounter cardiac arrest situations. Lack of adequate knowledge and training affects the quality of CPR.

Aim: To evaluate the effectiveness of a structured teaching programme (STP) on knowledge regarding adult CPR among 2nd-year B.Sc. Nursing students.

Methods: A quasi-experimental one-group pre-test post-test design was adopted. Forty-two students were selected using simple random sampling. A structured questionnaire consisting of 30 MCQs was used to assess knowledge before and after the STP.

Results: Pre-test results showed 33% had average, 62% good, and 5% very good knowledge. Post-test results showed 71% had well and 29% had very good knowledge. The mean difference between pre- and post-test scores was 11.35, indicating significant improvement.