ARCHIVES
VOL. 10, ISSUE 2 (2025)
Role of ATP usage in Breast cancer and metastasis
Authors
Hritik Chaudhary, Siddhant Mavi
Abstract
Breast cancer is still a major global health concern, and one of the
main causes of death for those who have it is metastasis. Although a great deal
of study has illuminated many facets of the biology of breast cancer, little is
known about the complex interactions between cellular energetics, namely the
use of adenosine triphosphate (ATP), and tumour growth and metastasis. With the
goal of providing insights into possible treatment paths, this research study
aims to clarify the complex role that ATP utilisation plays in promoting breast
cancer metastasis. In this paper we examined the basic principles that underlie
the synthesis and use of ATP in both healthy and malignant cells. Sometimes
called the "energy currency" of the cell. One of the main
characteristics of cancer cells is their dysregulated ATP metabolism, which
allows them to continue proliferative signalling, avoid growth suppressors, and
withstand cell death. Determining therapeutically targetable vulnerabilities
requires an understanding of the abnormal ATP utilisation pathways unique to breast
cancer cells. We also investigated the complex relationship with a particular
emphasis on metastasis between ATP utilisation and significant markers of
cancer progression. Cancer cells migrate from the main tumour to remote
locations through a complicated, multi-step process called metastasis,
which is regulated by a number of cellular and molecular factors. Furthermore,
the tumour microenvironment has a significant impact on the behaviour and
propensity for metastasis of cancer cells due to its altered ATP levels and
signaling. This article will additionally address new developments in ATP
utilisation pathway targeting as a possible treatment approach to prevent
breast cancer metastases. The preclinical models of breast cancer have shown
the ability of inhibitors of important ATP production-related enzymes, such as
glycolysis and oxidative phosphorylation, to reduce the spread of metastatic
cancer while improving treatment results. To further improve therapeutic
efficacy and disrupt the metastatic cascade, purinergic signalling pathways
which regulate ATP release and extracellular signaling, can be potentially
targeted. To sum up, the untangling of the complex function that ATP
utilisation plays in the advancement and spread of breast cancer is highly promising
in terms of creating novel therapeutic approaches. The objective of this
research is to improve patient outcomes and help with the ongoing fight over
metastatic breast cancer by clarifying the molecular mechanisms underlying
ATP-dependent actions in cancer cells and their peritoneum.
Download
Pages:47-54
How to cite this article:
Hritik Chaudhary, Siddhant Mavi "Role of ATP usage in Breast cancer and metastasis". International Journal of Advanced Scientific Research, Vol 10, Issue 2, 2025, Pages 47-54
Download Author Certificate
Please enter the email address corresponding to this article submission to download your certificate.