International Journal of Advanced Scientific Research

International Journal of Advanced Scientific Research


International Journal of Advanced Scientific Research
International Journal of Advanced Scientific Research
Vol. 6, Issue 2 (2021)

Vitamin E protects against biochemical alterations in testes of rats fed with photoxidised palm oil diet


Ekpe O Aribo, Ernest A Amama, Samuel E Urom

Palm oil is a widely consumed vegetable oil in Nigeria and many parts of the tropics. Photoxidized palm oil (PPO) diet has been linked with testicular dysfunction and systemic expression of oxidative stress markers. Effect of vitamin E on testicular biochemical changes in those rats were not evaluated in previous studies and hence this research. Male wistar rats weighing 100-150g were equally divided into 3 groups: control (group 1), PPO diet-only (group 2)and PPO diet + vitamin E(group 3).Feeding and vitamin E administration were done for 13 weeks. Animals were sacrificed and their testes harvested for evaluation of relevant parameters. Result shows malondialdehyde was significantly increased in group 2 compared with control (P<0.001) but reduced in group 3 compared with group 2 (P<0.01). Glutathione peroxidase was significantly increased in group 3 compared with control (P<0.01) and group 2 (P<0.01). Tumor necrosis factor-α was significantly increased in group 2 compared with control (P<0.001) but decreased in group 3compared with group 2 (P<0.001). C- reactive protein in the different groups was insignificant. We conclude that vitamin E protects against PPO-induced biochemical alterations and improves oxidative status in testes of rats.
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How to cite this article:
Ekpe O Aribo, Ernest A Amama, Samuel E Urom. Vitamin E protects against biochemical alterations in testes of rats fed with photoxidised palm oil diet. International Journal of Advanced Scientific Research, Volume 6, Issue 2, 2021, Pages 13-18
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