Achievement motivation and self-efficacy are considered as major variable that affects academic success of a student. This study is an attempt to investigate relationship between achievement motivation and self-efficacy. The study is also designed to find out gender differences in both the variables. Achievement motivation scale (n-ach) developed by Deo and Mohan (2011) scale and Self-efficacy questionnaire (SEQ) developed by Muris (2001) was used to measure the achievement motivation and Self-Efficacy of the school students respectively. T-test was used to check the significant difference and Karl Pearson’s coefficient of correlation was used to find out the relationship between variables. The results suggested that there is a significant correlation between achievement motivation and self-efficacy. However, finding of the second and third hypotheses shows no significant difference in achievement motivation and self-efficacy among senior secondary school students.