Antimicrobial resistance (AMR) is a universal public health problem affecting the benefit of antibiotics. Antibiotic use, inappropriate dosage, and genetics led to the spread of multidrug resistance among pathogenic bacteria, and it became hard to treat infections. Antibiotic resistance crisis is widespread and still increasing, due to continuous abuse of antibiotics and deficiency of the new antibiotic industry. A multifaceted plane is required to control the antibiotic resistance crisis. Educational programs and awareness campaigns are required. Research, explanations, and solutions should be implanted. Screening and diagnostic tools of antibiotic resistance should be improved and globally applied ^[1].