Statement: “A study to assess the effectiveness of planned teaching programme on knowledge regarding thermoregulation in neonate among the general nursing students in selected schools of nursing in selected city.” Objectives: 1) To assess the existing knowledge regarding thermoregulation in neonates among the general nursing students. 2) To evaluate the effectiveness of planned teaching program on knowledge regarding thermoregulation in neonate among general nursing students. 3) To find out the association between the pre-test knowledge score regarding thermoregulation in neonates with selected demographic variable. Methodology: Quantitative evaluative research Approach was used with one group pre experimental one group pretest post -test design, population was 50 General Nursing Students and simple random sampling technique was used for data collection. Result: In the present study majority of 48 (96%) General Nursing Students had adequate knowledge and no one general nursing student had inadequate knowledge and remaining 2(4%) of general nursing student had moderately adequate knowledge regarding thermoregulation in neonate.