This research was carried out to Survey and Study the Efficacy of some Local Plants used for the treatment and management of parasitic infections of cattle in Hong Local Government Area of Adamawa State. Ethnobotanical information collected from the rural dwellers are documented, thiswas a useful instrument in giving insight on the efficacy of the local plants against parasitic infection on cattle. The survey shows that plants such as A. digitata, V. amygdalina, A. indica, A. nilotica, C. procera, T. indica, P. biglobosa have multiple medicinal uses, also C. aurantiifolio, N. tabacum, K. senegalensis, B. aegyptiaca, H. sabdariffia, A. senegalensis, B. dalziellii were being used to cure two aliment disease, while S. hermontheca, P. guajava, C. papaya, Z. officinale, P. thonningii are use for curing one aliment disease in the study area. Out of the 29 plants species identified during the survey, the family Mimosaceae, Fabaceace, Malvaceace, Alliaceace, Zingibecaceace and Solanaceace are most mentioned frequently for their effectiveness in the community of the study area. Plants such as V. amygdalina, K. senegalensis and T. indica have been demonstrated to be highly effective in the treatment of helminthosis in cattles in the study area which is relatively rich in medicinal plant knowledge and practice.Vernonia amygdalina 15.0% and Khaya senegalensis 18.9% and Calotropi sprocera 9.4% are commonly used local plant in the study sites.Therefore,proper conservation of medicinal plants, documentation as well as promotion of indigenous knowledge by encouraging research activities is highly required in the study area.