The research was carried out to investigate whether there was an association between ABO blood groups and cardiovascular diseases in Nigerian population. The present retrospective study analyzed ABO blood groups among 721 patients with documented CVD, who were treated at Ahmadu Bello University Teaching Hospital (ABUTH) in Zaria city from January 2017 to February, 2018 comparing with a control group of 120 subjects. Data were analyzed with computer software MS-Excel SPSS and Minitab by using cross tabulation, ANOVA and Latin square design. A p-value less than 0.05 were considered as statistically significant. Also significant difference in distribution of ABO blood groups was seen in patients with CVD (A, 32%; B, 26%; AB, 11%; O, 31%) and also after adjustment for common cardiovascular risk factors such as age, gender, (A, 24%; B, 27%; AB, 12%; O, 36%) as compared to the controls (A, 22%; B, 23%; AB, 20%; O, 34%), p value = 0.000 respectively. The findings of the study suggest that there seems to be no correlation between various ABO blood groups and development of cardiovascular diseases. Moreover, the prevalence of major risk factors was not equal in patients with different blood groups and blood groups had impact on development of cardiovascular pathogenesis in individual subjects.