Intravenous cannulation is a common invasive procedure which is performed in hospital for providing drugs, nutrients and blood products these are associated with complications. The Objective of the study was to find out the level of knowledge and practice on intravenous cannulation among staff nurses of selected Hospital. The study was descriptive type of cross-sectional study. The instruments used for the study were self-developed questionnaire and practice observational checklist. Methods: A comprehensive systemic search of published literature and journal article from PubMed, EBESCO, to assess knowledge and practice regarding intravenous cannulation among staff nurses that are focusing from 2008 to 2017. Search strategy specific to each database was used. Results: During search 9960 titles were retrieved and after screening 7 articles were selected based on the inclusion criteria. Conclusion: Inservice education programme is effective in improving knowledge and practice regarding intravenous cannulation. Regular supervision also improves nurses.