The present paper deals with the experimental investigation on compressive strength characteristics of partially cement replaced phosphogypsum concrete using 0%., 10%, 15% and 20% replacement with water-binder ratio of 0.40. The strength characteristics are studied by casting and testing cube specimens for 7, 14 and 28 days. It is shown that a part of ordinary Portland cement can be replaced with phosphogypsum to develop a good and hardened concrete to achieve economy; above 10% replacement of phosphogypsum in concrete lead to drastic reduction not only in the compressive strength.