The aim of this study was to determine the resistance of Klebsiella pneumoniae to beta-lactams, fluoroquinolones and aminoglycosides in hospitalized patients. From January 2011 to June 2016, 350 Klebsiella pneumoniae were isolated from various biological products and identified by standard bacteriological tests. The antibacterial sensitivity was determined by the disk diffusion method. The production of expanded-spectrum beta-lactamase was determined by the double-synergistic method. Of the 350 strains, 91 were producing broad-spectrum beta-lactamase. Resistance levels were 90.1%, 54.9% and greater than 90%, respectively, for aztreonam, amoxicillin + clavulanic acid and for third generation cephalosporins. Imipenene and cefoxitin were the most active molecules with respectively 1% and 31.8% of the resistant strains. Concerning the classes of antibiotics quinolone and aminoside, the isolates had a resistance rate higher than 50% except amikacin (4.4%). The emergence of multiresistant Klebsiella pneumoniae is a real public health problem in Cote d’Ivoire.