Context: Seborrheic Dermatitis (SD) and dandruff are of a continuous spectrum of the same disease that affects the seborrheic areas of the body. Aims: to evaluate potency of Azadirachta indica (neem) Reetha (Sapindus mukorossi), shikakai (Acacia concinna), hibiscus flower (Hibiscus sabdariffa) oil and Lemon in resistance cases of dandruff to shampoo and conditioner containing Pyrithione Zinc, Coal Tar, Salicylic Acid, Selenium Sulfide and Ketoconazole. Settings and Design: This was a longitudinal study done on the subject randomly selected from attending private OPD for the dandruff problem. Methods and Material: Group 1 (n=88) consists of the patient who was treated with shampoo and conditioner containing Pyrithione Zinc, Coal Tar, Salicylic Acid, Selenium Sulfide and Ketoconazole. Group 2 (n=28) consists of the patient selected from 58 patients who does not responded to treatment (group1) and were given Neem (Azadirachta indica), Reetha (Sapindus mukorossi), shikakai (Acacia concinna), hibiscus flower (Hibiscus sabdariffa) oil and Lemon. Scale and scalp itching were compared amongst two groups. Statistical analysis used: chi-square test. Results: Significant reduction in scalp itching and scale were seen in group 2. Conclusions: Neem (Azadirachta indica), Reetha (Sapindus mukorossi), shikakai (Acacia concinna), hibiscus flower (Hibiscus sabdariffa) oil and Lemon can be used as natural antidandruff agents.