Dengue and Malaria are diseases which are transmitted through the bite of mosquitoes from one host to another i.e. they are vector borne disease which grosses a large amount of deaths in many countries throughout the world. Various environmental spatial factors have effect on these diseases, they prosper well and transmit the parasite in moisture laden areas in warmer climates. The best ecology are near residential areas where animal and human cohabitate. These diseases have been reported for high infant mortality rate and the reports are increasing every day in our country. Our objective is to identify the ecology and the transmission of mosquitoes for reducing their production. This study provides us data from past and helps us to determine the future role of GIS integrated epidemiological indices for identifying risk areas. Various epidemiological indexes like ABER, API, SPR, SFR were studied to understand Dengue and Malaria epidemicity in UP cities and aimed to look for any link between these epidemiological indices.