Vol. 5, Issue 1 (2020)
to evaluate the effectiveness of locally delivered 25 % metronidazole gel as an adjunct to scaling and root planing in the treatment of chronic periodontitis: A randomized clinical controlled trial
Author(s): Dr Kompal Gautam, Dr Anjali Kapoor, Dr. Aparna Choudhary, Dr. Arpana Shekhawat
Abstract: Aim: To evaluate the clinical & microbiological effectiveness of locally delivered 25 % metronidazole gel along with scaling and root planing in the treatment of chronic periodontitis compared to placebo gel. Methodology: A randomized controlled clinical study with a split mouth design was conducted involving 40 sites in the chronic periodontitis patients with clinical attachment loss(CAL) of ≥ 5mm and probing pocket depth (PPD) of ≥ 5mm were included in the study. Using computer generated series of random numbers, the sites are randomly assigned into two treatment groups- i.e Test group- Group I in which Scaling and root planing + subgingival insertion of 25% metronidazole gel was done at day 1 and day 7 and Control group – Group 2 in which Scaling and root planing + subgingival insertion of placebo gel was done at day 1 and day 7. Clinical examination for Probing pocket depth, Relative attachment level, Plaque index (PI), gingival index (GI) measurement was done. For microbiological assessment, anaerobic microbial culture was prepared to count the colonies causing periodontal destruction. Data obtained was compiled on a MS Office Excel Sheet (v 2010) and subjected to statistical analysis using Statistical package for social sciences (SPSS v 22.0, IBM). Results: Results showed significant difference seen with intergroup comparison of Post-op GI, with higher mean for GI for Group 2.( p<0.01).There was a statistically highly significant difference seen between Pre-op and Post-op of all variables in group 1 & 2 (p<0.01). There was a statistically significant difference seen between group 1 & 2 for Bacterial Count cfu/ml (p<0.01) with higher no of patients having lower scores in group 1 while higher no of patients with higher scores in group 2. Conclusion: Antibiotic therapies resulted in greater improvement in microbiological parameters when compared to mechanotherapy alone.