Vol. 4, Issue 2 (2019)
Organogenesis & morphogenesis of cerebellum in human foetuses at different weeks of gestation
Author(s): Arpan Haldar, Sanjukta Sahoo, Soumya Chakraborty, Provas Banerjee, Dipti Basu
Abstract: The aim of present study is to describe the prenatal histogenesis of human cerebellar cortex of various weeks of gestation. This study was done to demonstrate the various histological features of foetal cerebellum in aborted human foetuses of different gestational ages received by spontaneous miscarriages and therapeutic abortions for analysing the cerebellar histology. The dissected specimens were preserved in 10%formalin and subjected to routine histological procedure for age related histogenesis and developmental anatomy. Histogenesis of cerebellum is observed from 10 weeks to 30 weeks of gestational age by dividing the specimens into six gestational 3 age groups (group A to group C). External granular layer is observed at 13-16 weeks of gestation and Purkinje cell layer is arranged at 20 weeks as a multi-layered and single layer at 26 weeks of gestation. The knowledge of cerebellar anatomy has a tremendous role in neurosurgical importance in surgeries of posterior fossa neoplasm mainly Medulloblastoma. Future investigations might involve evaluation of the cerebellum at other gestational ages.
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